Thermo Fisher Scientific NF Monoclonal Antibody (OTI3F7), TrueMAB
인간 Neurofilament 단백질을 인식하는 단클론 항체로 Western blot 및 IHC(P)에서 사용 가능. 고순도의 Affinity chromatography 정제 항체. PBS/BSA/glycerol buffer로 안정화되어 장기 보관 가능. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F7 |
| Immunogen | Synthetic peptide corresponding to the conserved region of human neurofilament heavy polypeptide (NEFH), medium polypeptide (NEFM), and light polypeptide (NF68, NEFL) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Synthetic peptide sequence: EYQDLLNVKMALDIEIAAYRKLLEGEE
Target Information
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. They form the axoskeleton and maintain neuronal caliber, playing a role in intracellular transport to axons and dendrites.
The NEFM gene encodes the medium neurofilament protein, a common biomarker of neuronal damage.
Alternative splicing produces multiple transcript variants encoding distinct isoforms.
Diseases associated with NEFM include Pineal Parenchymal Tumor of Intermediate Differentiation and Wallerian Degeneration. Related pathways include Amyotrophic Lateral Sclerosis (ALS) and Neural Stem Cell Differentiation Pathways.
Gene Ontology (GO) annotations: structural molecule activity, structural constituent of cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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