Thermo Fisher Scientific GADD45GIP1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
ELEAEEREWY PSLATMQESL RVKQLAEEQK RRER

Antigen sequence identity:

• Mouse: 74%
• Rat: 79%

Target Information

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is a serine kinase that plays an essential role in the NF-κB signaling pathway, activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or other cellular stresses. IKKβ acts as part of the canonical IKK complex in the conventional pathway of NF-κB activation and phosphorylates inhibitors of NF-κB on two critical serine residues. These modifications allow polyubiquitination and subsequent degradation of the inhibitors by the proteasome. Free NF-κB then translocates into the nucleus and activates transcription of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKKβ gene can result in Immunodeficiency 15 (IMD15).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.