Thermo Fisher Scientific Erythropoietin (EPO) Recombinant Rabbit Monoclonal Antibody (EPO, 3793R)

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 2–4 µg/mL

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed):
  Incubate antibody for 30 min at room temperature (RT).
  Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris Buffer with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at RT for 20 min.

Target Information

Erythropoietin (EPO) is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. It induces the final maturation of partially differentiated erythroid cells and the production of red cell–specific proteins such as hemoglobin.
The EPO receptor (EPOR) is expressed at higher levels on precursor cells and decreases with maturation.
In the fetus, hepatocytes are the main source of EPO, while in adults, interstitial kidney cells are the primary producers. EPO expression increases during hypoxia and can also be detected in lung and brain tissues under such conditions.
Recent studies suggest EPO may contribute to neuronal tissue protection and repair initiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.