Thermo Fisher Scientific SCN1B Polyclonal Antibody
SCN1B 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 ELISA에 최적화됨. 인간, 마우스, 랫트 반응성. Affinity Chromatography로 정제된 액상 형태. -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 19–160 of human SCN1B (NP_9502381) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.52 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804290 |
Product Specific Information
Immunogen sequence:
GGCVEVDSET EAVYGMTFKI LCISCKRRSE TNAETFTEWT FRQKGTEEFV KILRYENEVL QLEEDERFEG RVVWNGSRGT KDLQDLSIFI TNVTYNHSGD YECHVYRLLF FENYEHNTSV VKKIHIEVVD KGESGAACPF TV
Positive Samples: SH-SY5Y, A-549, HeLa, MCF7, Mouse brain, Rat brain
Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
Voltage-gated sodium channels are heteromeric proteins responsible for the generation and propagation of action potentials in muscle and neuronal cells. They consist of one alpha and two beta subunits, where the alpha subunit provides channel activity, and the beta-1 subunit modulates the kinetics of channel inactivation.
The SCN1B gene encodes the sodium channel beta-1 subunit. Mutations in this gene are associated with generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and cardiac conduction defects. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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