Thermo Fisher Scientific UBE3B Polyclonal Antibody
Human UBE3B 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC, ICC/IF, PLA 실험에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 고순도 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- PA559390
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | View 1 publication |
| in situ PLA (PLA) | - | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UBE3B. Recombinant protein control fragment (Product #RP-97787). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649187 |
Product Specific Information
Immunogen sequence:
ANIMGHLNQH GFYSVLQILL TRGLARPRPC LSKGTLTAAF SLALRPVIAA QFSDNLIRPF LIHIMSVPAL VTHLSTVTPE RLTVLESHDM LRKFIIFLRD QDRCRDV
Highest antigen sequence identity to the following orthologs:
- Mouse: 87%
- Rat: 85%
Target Information
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
- E1 ubiquitin-activating enzymes
- E2 ubiquitin-conjugating enzymes
- E3 ubiquitin-protein ligases
This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 enzyme and transfers it to target substrates.
A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform acts as the catalytic site for ubiquitin transfer and forms a complex with E2 conjugases.
Shorter isoforms lacking the C-terminal HECT domain are unlikely to bind E2 enzymes.
Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-59390_UBE3B_Q7Z3V4-1_Rabbit.svg
- PA5-59390_UBE3B_Q7Z3V4-1_Rabbit_PDP.jpeg
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