Thermo Fisher Scientific NPPB Monoclonal Antibody (OTI6F8), TrueMAB
인간 NPPB 단백질을 인식하는 마우스 단일클론 항체로, WB, IHC, Luminex 등 다양한 응용에 사용 가능. 고순도 친화 크로마토그래피 정제, 동결건조 형태로 제공. 심혈관 연구 및 심부전 관련 바이오마커 분석에 적합.
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Thermo Fisher Scientific NPPB Monoclonal Antibody (OTI6F8), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Luminex (LUM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6F8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 27–102 of human NPPB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The NPPB gene encodes a secreted cardiac hormone that belongs to the natriuretic peptide family. It undergoes two cleavage events—one intracellular and one extracellular after secretion.
Biological actions include:
- Natriuresis and diuresis
- Vasorelaxation
- Inhibition of renin and aldosterone secretion
- Regulation of cardiovascular homeostasis
Elevated levels in blood indicate heart failure. Mutations are associated with postmenopausal osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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