Thermo Fisher Scientific TG Monoclonal Antibody (OTI8F7), TrueMAB
인간 Thyroglobulin을 표적으로 하는 마우스 단클론 항체로, IHC(P)에서 1:150 희석 비율로 검증됨. TrueMAB 형식의 고순도 항체로 Affinity Chromatography로 정제됨. 연구용으로만 사용되며, -20°C에서 보관 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8F7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 20–358 of human TG produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones T4 and T3.
Thyroid disorders are largely autoimmune in origin, and anti-thyroglobulin autoantibodies were among the first factors discovered. Anti-hTG is found in all thyroid autoimmune diseases (Hashimoto thyroiditis, Graves disease), with the highest levels observed in Hashimoto thyroiditis.
Anti-hTG is also characteristic of thyroid cancer and can be used for follow-up of cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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