Thermo Fisher Scientific CD45 Polyclonal Antibody
Human CD45 단백질을 인식하는 Rabbit Polyclonal 항체로 IHC(P) 실험에 적합합니다. 보존제가 포함되지 않아 오염 방지를 위해 sodium azide 첨가를 권장합니다. Protein A 및 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공됩니다.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:250–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human CD45/PTPRC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788521 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human CD45.
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising about 10% of surface proteins in lymphocytes. It is absent in non-hematopoietic tissues and cell lines.
CD45 plays a crucial role in lymphocyte development and antigen signaling by regulating Src-family kinases. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing common transmembrane and cytoplasmic regions.
CD45RA, one isoform, shows restricted expression among lymphoid cell subtypes. Isoforms vary in localization to lipid rafts and expression depending on cell type and physiological state.
CD45 is essential in T- and B-cell receptor signaling, suppresses JAK kinases in cytokine receptor pathways, and modulates integrin-mediated signaling, apoptosis, and immune regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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