Thermo Fisher Scientific ESRRB Monoclonal Antibody (OTI12B7), TrueMAB
ESRRB 단백질을 인식하는 Mouse Monoclonal 항체로, Western Blot에 적합합니다. Human 시료에 반응하며, 동결건조 형태로 제공됩니다. PBS buffer에 trehalose가 포함되어 안정성이 우수합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI12B7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–252 of human ESRRB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
ESRRB (steroid hormone receptor ERR2) plays a crucial role in maintaining self-renewal and pluripotency of embryonic and trophoblast stem cells through multiple signaling pathways, including FGF and Wnt.
Upon FGF pathway activation, ESRRB interacts with KDM1A and activates transcription of ELF5 and EOMES, promoting self-renewal of trophoblast stem cells.
It also regulates expression of rod-specific genes essential for cell survival.
Mutations in ESRRB can cause autosomal recessive deafness (DFNB35).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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