Thermo Fisher Scientific CRYAB Monoclonal Antibody (OTI4A6), TrueMAB
CRYAB 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC, Flow cytometry, IP 등에 사용 가능. Human 시료에 반응하며, 액상 형태로 1 mg/mL 농도 제공. PBS, BSA, 글리세롤 완충액에 보관되며 -20°C에서 안정적.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | 2 µg/500 µL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A6 |
| Immunogen | Full length human recombinant CRYAB protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index. The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest and composed of two primary gene products, alpha-A and alpha-B.
Alpha-crystallin comprises approximately 40% of total lens protein composition and functions as a chaperone to prevent aggregate formation that may lead to cataracts. Phosphorylated states of alpha-crystallin may occur in response to cellular stress, serving structural control and protein maintenance roles. Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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