Thermo Fisher Scientific SMC1 Polyclonal Antibody
SMC1 단백질을 인식하는 Goat Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 적합합니다. 액상 형태이며 1 mg/mL 농도로 제공됩니다. 인간 SMC1(1183–1233 aa)을 면역원으로 제작되었으며, 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1183 and 1233 of Human Structural Maintenance of Chromosomes 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair, and global transcriptional repression.
These proteins are conserved in eukaryotes and are essential for mitotic chromosome dynamics.
SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells, responsible for sister chromatid cohesion during metaphase.
Mutations in the SMC1 gene can lead to Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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