Thermo Fisher Scientific ABCC1 (MRP1) Polyclonal Antibody
ABCC1(MRP1) 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 사용 가능. 합성 펩타이드(aa 280-330)를 면역원으로 제작. Lyophilized 형태, whole serum 기반, 무보존제. 연구용으로만 사용.
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- OSA00249W-100UL
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 280–330 of human ABCC1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: ABCC1.
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White.
This full transporter belongs to the MRP subfamily, which is involved in multi-drug resistance. It functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates.
It also transports glucuronides and sulfate conjugates of steroid hormones and bile salts.
Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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