Thermo Fisher Scientific COPS6 Monoclonal Antibody (OTI2H4), TrueMAB
COPS6 단백질을 표적으로 하는 Mouse monoclonal antibody로, Western blot에 최적화되어 있습니다. Human 시료에 반응하며, E. coli에서 생산된 재조합 단백질을 면역원으로 사용했습니다. Lyophilized 형태로 제공되며, -20°C에서 보관합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 58–327 of human COPS6 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
The protein encoded by the COPS6 gene is one of eight subunits of the COP9 signalosome, a conserved protein complex that regulates multiple signaling pathways.
Its structure and function are similar to the 19S regulatory particle of the 26S proteasome.
COP9 signalosome interacts with SCF-type E3 ubiquitin ligases and acts as a positive regulator of these ligases.
COPS6 belongs to the translation initiation factor 3 superfamily and is involved in cell cycle regulation, potentially serving as a cofactor for HIV-1 accessory gene product Vpr.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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