Thermo Fisher Scientific CD13/Aminopeptidase-N (Myeloid Cell Marker) Monoclonal Antibody (APN/6998)
CD13/Aminopeptidase-N 단백질을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. Western blot, IHC, ELISA 등 다양한 응용에 적합하며, Protein A/G 정제 및 보존제 무첨가 PBS 용액 형태로 제공됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL | |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | APN/6998 |
| Immunogen | Recombinant fragment (around aa 50–250) of human ANPEP protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD13 (ANPEP) is a 150–170 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types.
It is a metalloprotease that catalyzes the removal of neutral amino acids from small peptides, thereby activating or inactivating bioactive peptides.
CD13 plays roles in extracellular matrix degradation, antigen processing, and signal transduction. It is important in inflammatory responses, regulation of intercellular contact, cell motility, and vascularization.
CD13 is expressed by granulocytes, monocytes, and myeloid leukemia cells, and is associated with protection of leukemic cells against apoptosis and poor prognosis in carcinomas.
Additionally, CD13 functions as an aminopeptidase enzyme and serves as an alpha receptor for coronavirus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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