Thermo Fisher Scientific SMC5 Polyclonal Antibody
SMC5 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. Western blot과 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 4°C에서 보관하며 연구용으로만 사용 가능합니다.
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- A300236Ax (2개 옵션)
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- pk
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SMC5 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 1050 and the C-terminus (residue 1101) of Human Structural Maintenance of Chromosomes 5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Core component of the SMC5–SMC6 complex, which is involved in the repair of DNA double-strand breaks by homologous recombination. This complex may promote sister chromatid homologous recombination by recruiting the SMC1–SMC3 cohesin complex to double-strand breaks. It is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex components, leading to shelterin complex disassembly in ALT-associated PML bodies (APBs). Also required for recruitment of telomeres to PML nuclear bodies and for sister chromatid cohesion during prometaphase and mitotic progression, independent of SMC6. The SMC5–SMC6 complex may prevent transcription of episomal DNA such as circular viral DNA genomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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