Thermo Fisher Scientific MCSF Receptor Polyclonal Antibody
MCSF Receptor를 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. 다양한 면역학적 실험(IHC, ICC, Flow, ELISA)에 적합하며, Protein A로 정제된 고순도 항체입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human MCSF receptor, amino acids 201–300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through oligomerization and transphosphorylation.
CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases.
Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.
Tyrosine-protein kinase acts as a cell-surface receptor for CSF1 and IL34, playing an essential role in survival, proliferation, and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes such as macrophages and monocytes.
Promotes release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammatory processes.
The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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