Thermo Fisher Scientific CD104 Monoclonal Antibody (10B10D5)
Human ITGB4 단백질을 표적으로 하는 CD104 단클론 항체로, WB, IHC, ICC/IF, Flow Cytometry 등에 사용 가능. Mouse IgG1 형식의 비결합 항체이며, 고순도 Protein G 정제. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | View 1 publication |
| Flow Cytometry (Flow) | 1:200–1:400 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10B10D5 |
| Immunogen | Purified recombinant fragment of human ITGB4 (amino acids 1619–1822) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538575 |
Product Specific Information
MA5-17104 targets ITGB4 in FACS, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human ITGB4 (amino acids 1619–1822) expressed in E. coli.
MA5-17104 detects ITGB4, which has a predicted molecular weight of approximately 202 kDa.
Target Information
Integrins are heterodimeric transmembrane glycoprotein receptors composed of alpha and beta subunits.
Different combinations of these subunits determine ligand-binding specificity and mediate cell-matrix or cell-cell adhesion.
Integrin β4 (CD104) acts as a receptor for laminins and associates with the α6 subunit, playing a pivotal role in invasive carcinoma biology.
Mutations in this gene are linked to epidermolysis bullosa with pyloric atresia.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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