Thermo Fisher Scientific ELAC2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ELAC2 protein. Validated for WB, IHC, IHC-P, and IP applications. Recommended dilution 1:500–1:5,000. Suitable for research use; predicted cross-reactivity with Gorilla and Chimpanzee.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 150–200 of human Zinc phosphodiesterase ELAC protein 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Predicted to react with Gorilla and Chimpanzee based on 100% sequence identity
Target Information
ELAC2 encodes a protein with tRNA 3′ processing endoribonuclease activity, responsible for removing the 3′ trailer from precursor tRNAs. It interacts with Smad2 and forkhead box H1 (FAST-1), influencing TGF-β–induced growth arrest. Mutations in ELAC2 are associated with increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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