Thermo Fisher Scientific NPR1 Polyclonal Antibody
NPR1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 반응성으로 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제된 액상 항체이며, -20°C 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2635939 |
Product Specific Information
The antibody detects endogenous levels of total NPR1 protein.
Target Information
Guanylyl cyclases catalyze the production of cGMP from GTP and are classified into soluble and membrane forms. The membrane guanylyl cyclases (A–F) are cell-surface receptors with similar structures: extracellular ligand-binding domain, single transmembrane domain, and intracellular kinase-like plus cyclase catalytic domains.
GC-A and GC-B serve as receptors for natriuretic peptides (atrial and type B). NPR1 is a membrane-bound guanylate cyclase acting as the receptor for both atrial and brain natriuretic peptides (BNP).
Also refer to NPR3, which encodes a protein with ligand-binding transmembrane and short cytoplasmic domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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