Thermo Fisher Scientific Tankyrase 1 Polyclonal Antibody
Tankyrase 1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등에 사용 가능. Human에 반응하며 Mouse에도 예측 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로, 4°C에서 보관. 연구용으로만 사용.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 5–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1277 and 1327 of Human TRF1-interacting ankyrin-related ADP-ribose polymerase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length regulation, and vesicle trafficking.
Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, leading to their ubiquitination and degradation.
Also mediates PARsylation of BLZF1, CASC3, and TERF1, contributing to telomere length regulation and centrosome maturation.
May regulate vesicle trafficking and spindle pole assembly, and stimulates 26S proteasome activity.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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