Thermo Fisher Scientific DENND1C Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human DENND1C. Recombinant protein control fragment (Product #RP-99238). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DENND1C,uniProtId:Q8IV53-1,ncbiNodeId:9606,antigenRange:710-800,antigenLength:801,antigenImageFileName:PA5-60105_DENND1C_Q8IV53-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60105_DENND1C_Q8IV53-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640513

Product Specific Information

Immunogen sequence: PSPPESPQIL APTKPNFDIA WTSQPLDPSS DPSSLEDPRA RPPKALLAER AHLQPREEPG ALNSPATPTS NCQKSQPSSR PRVADLKKCF E

Highest antigen sequence identity to the following orthologs: Mouse - 47%, Rat - 45%.

Target Information

Clathrin-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 and bind to clathrin and clathrin adaptor protein-2. Thus, connecdenns link RAB35 activation with the clathrin machinery.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.