Thermo Fisher Scientific PARP1 Polyclonal Antibody
PARP1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IF에 사용 가능. 사람, 생쥐, 랫드, 소 시료에 반응. C-말단 합성 펩타이드로부터 유래된 면역원 사용. 액상 형태로 4°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,500 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 | - |
| Immunocytochemistry (ICC/IF) | 2–3 µg/mL | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of bovine PARP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985586 |
Product Specific Information
PA5-16561 was successfully used to detect PARP in WB, IHC, and IF applications.
It targets PARP (Poly ADP-Ribose Polymerase) in WB applications and shows reactivity with mouse, rat, bovine, and human samples.
The PA5-16561 immunogen is a synthetic peptide from the C-terminal region of bovine PARP.
Target Information
Poly ADP-Ribose Polymerase (PARP) uses nicotinamide adenine dinucleotide (oxidized form) NAD as a substrate to catalyze the transfer of ADP-ribose to various nuclear protein acceptors.
Proteolysis of PARP to its stable 85 kDa fragment is an early marker of programmed cell death (apoptosis) and is mediated by the caspase CPP32 protein.
Cleavage occurs between Asp216 and Gly217, a site conserved across species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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