Thermo Fisher Scientific TRPV6 Polyclonal Antibody
Zebrafish 유래 TRPV6 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot과 IHC에 사용 가능. PBS 기반, 무방부제 동결건조 형태. 4°C 단기 보관, -20°C 장기 보관 권장. 연구용으로만 사용.
- 카탈로그번호
- OST00068G-500UG
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Zebrafish |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from zebrafish TRPV6, conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: TRPV6.
Target Information
Calcium-permeable channels such as TRPV6 are involved in neurotransmission, muscle contraction, and exocytosis by mediating intracellular calcium signaling. Depending on tissue type, calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
TRPV6 acts as a calcium-selective cation channel involved in Ca²⁺ uptake in various tissues, including intestinal reabsorption. The channel is activated by low internal calcium levels and exhibits inward rectification.
Inactivation occurs via rapid Ca²⁺-dependent and slower Ca²⁺-calmodulin-dependent mechanisms, possibly regulated by phosphorylation. In vitro, it is slowly inhibited by Mg²⁺ in a voltage-independent manner.
TRPV6 forms heteromeric assemblies with TRPV5, altering channel properties. TRPV5–TRPV6 heteromultimers exhibit voltage-dependent gating. TRPV6 interacts with TRPV5, S100A10, ANAX2–S100A10 heterotetramer, BSPRY, and calmodulin. Interaction with S100A10 is essential for plasma membrane trafficking.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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