Thermo Fisher Scientific TRPV6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 500 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: TRPV6.

Target Information

Calcium-permeable channels such as TRPV6 are involved in neurotransmission, muscle contraction, and exocytosis by mediating intracellular calcium signaling. Depending on tissue type, calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
TRPV6 acts as a calcium-selective cation channel involved in Ca²⁺ uptake in various tissues, including intestinal reabsorption. The channel is activated by low internal calcium levels and exhibits inward rectification.
Inactivation occurs via rapid Ca²⁺-dependent and slower Ca²⁺-calmodulin-dependent mechanisms, possibly regulated by phosphorylation. In vitro, it is slowly inhibited by Mg²⁺ in a voltage-independent manner.
TRPV6 forms heteromeric assemblies with TRPV5, altering channel properties. TRPV5–TRPV6 heteromultimers exhibit voltage-dependent gating. TRPV6 interacts with TRPV5, S100A10, ANAX2–S100A10 heterotetramer, BSPRY, and calmodulin. Interaction with S100A10 is essential for plasma membrane trafficking.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.