Thermo Fisher Scientific MLH1 Polyclonal Antibody
MLH1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, 고순도 Protein A 정제 및 안정적 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human MLH1, amino acids 501–600 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MLH1 is a DNA mismatch repair protein. The repair of mismatched DNA is essential to maintaining the integrity of genetic information over time. Alterations of microsatellite repeats result from slippage during DNA replication, referred to as microsatellite instability (MSI). Defects in DNA repair pathways have been linked to human carcinogenesis, notably hereditary nonpolyposis colon cancer (HNPC). MSH2 is involved in the initial recognition of mismatched nucleotides, and after binding to a mismatched DNA duplex, it forms a heterodimer with MLH1 and PMSH to facilitate subsequent repair steps.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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