Thermo Fisher Scientific NPC1 Polyclonal Antibody
Human NPC1 단백질을 인식하는 Goat Polyclonal Antibody로 Western blot에 적합. Peptide ELISA에서 높은 감도(1:128,000) 확인. 0.5 mg/mL 농도의 액상 시약으로 -20°C 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–1.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-TYHTVLQTSADFID (aa 1040–1053) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933228 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by abnormal lipid sequestration, including cholesterol and glycosphingolipids.
The NPC1 protein resides in the limiting membrane of endosomes and lysosomes, mediating intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain.
NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments, where they are hydrolyzed and released as free cholesterol.
NPC1, along with FTO, MC4R, and PTER, has been identified as a new risk locus for early-onset and morbid adult obesity in European populations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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