Thermo Fisher Scientific HIF3A Polyclonal Antibody
HIF3A 단백질을 인식하는 염소 유래 폴리클로날 항체로, 인간 시료에 반응합니다. IHC(P) 실험에 적합하며 고감도의 특이적 결합을 제공합니다. 액상 형태로 공급되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 4–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence QDHRSTTELRKEKS-C (aa 3–17) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933226 |
Product Specific Information
- This antibody is expected to recognize isoform a and c (NP_690007.1; NP_690008.2).
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Cell growth and viability are compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1 alpha, HIF-1 beta (Arnt 1), EPAS-1 (HIF-2 alpha), and HIF-3 alpha, induce glycolysis, erythropoiesis, and angiogenesis to restore oxygen homeostasis.
These factors belong to the Per-Arnt-Sim (PAS) domain transcription factor family. Under hypoxic conditions, HIF-1 alpha is upregulated and forms a heterodimer with Arnt 1 to create the HIF-1 complex, which binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, activating transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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