Thermo Fisher Scientific TAS2R41 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

-

Immunohistochemistry (IHC)

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TAS2R12, corresponding to a region within C-terminal amino acids. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TAS2R41,uniProtId:P59536-1,ncbiNodeId:9606,antigenRange:307,antigenLength:307,antigenImageFileName:PA5-99927_TAS2R41_P59536-1_Rabbit.svg,antigenImageFileNamePDP:PA5-99927_TAS2R41_P59536-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2818860

Product Specific Information

Antibody detects endogenous levels of total TAS2R12.

Target Information

TAS2R41 is a receptor that may play a role in the perception of bitterness and belongs to the G-protein receptor superfamily. TAS2R41 is expressed mainly in taste receptor cells of the tongue and the palate eptithelia. Structurally, the TAS2R41 gene encodes a seven trans-membrane receptor protein and is clustered together with eight other taste receptor genes on chromosome 7. The compound chloramphenicol is an agonist for the TAS2R41 protein. Further, TAS2R41 may play a role in sensing the chemical composition of the gastrointestinal content. The activity of TAS2R41 may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. TAS2R41 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.