Thermo Fisher Scientific JMY Polyclonal Antibody
JMY 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC 및 IHC(P) 실험에 적합하며, 인간 및 여러 포유류 종에 반응 예측. 액상 형태로 제공되며 항원 친화 크로마토그래피로 정제된 고순도 항체.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human junction mediating and regulatory protein (JMY) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Bovine, Dog, Guinea pig, Panda, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Little brown bat.
Target Information
JMY acts both as a nuclear p53/TP53 cofactor and a cytoplasmic regulator of actin dynamics depending on conditions.
In the nucleus, it increases p53/TP53-dependent transcription and apoptosis through interaction with p300/EP300, playing an important role in stress responses such as DNA damage.
In the cytoplasm, JMY functions as a nucleation-promoting factor for both branched and unbranched actin filaments, activating the Arp2/3 complex and catalyzing actin polymerization.
It contributes to cell motility by controlling actin dynamics and promoting rapid formation of branched actin networks.
The activities of JMY are regulated via its subcellular localization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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