Thermo Fisher Scientific DUSP1 Monoclonal Antibody (OTI4F10), TrueMAB
인간 DUSP1 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot에 적합합니다. TrueMAB 포맷으로 생산되었으며, E.coli에서 발현된 full-length 단백질로 면역화되었습니다. PBS/BSA/glycerol 버퍼에 보관하며, 연구용으로만 사용됩니다.
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Thermo Fisher Scientific DUSP1 Monoclonal Antibody (OTI4F10), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4F10 |
| Immunogen | Full length human recombinant protein of human DUSP1 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors.
It encodes a protein structurally similar to non-receptor-type protein-tyrosine phosphatases and shows significant sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus.
The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by dephosphorylating both phosphothreonine and phosphotyrosine residues.
It also suppresses MAP kinase activation by oncogenic ras in extracts of Xenopus oocytes.
Thus, DUSP1 may play an important role in the human cellular response to environmental stress and in the negative regulation of cellular proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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