Thermo Fisher Scientific AADACL2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human AADACL2 protein. Validated for IHC (Paraffin). Purified by antigen affinity chromatography. Supplied in PBS with 40% glycerol, stored at -20°C. For research use only.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the C-terminal of human arylacetamide deacetylase-like 2 (AADACL2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635739 |
Product Specific Information
This antibody detects endogenous levels of total AADACL2 protein.
Target Information
AADAC is a 45 kDa membrane-associated hydrolase highly expressed in the human liver, implicated in the hydrolysis of arylacetamide xenobiotics such as flutamide and phenacetin.
AADAC is homologous to related lipases AADACL1, AADACL2, and AADACL4, the latter two being largely unannotated.
Overexpression of AADAC in rat hepatoma cells alters triglyceride levels, apolipoprotein B secretion, and fatty acid oxidation, though the underlying mechanisms remain unclear.
Endogenous substrates, selective inhibitors, or knockout models for AADAC, AADACL2, and AADACL4 have not yet been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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