Thermo Fisher Scientific B7-H4 Polyclonal Antibody
B7-H4 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능. 항원 친화성 크로마토그래피로 정제되었으며 PBS 버퍼에 50% 글리세롤로 안정화. 인간 및 랫드 시료에 반응.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human B7-H4 aa 25–259 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2913227 |
Product Specific Information
- Positive Control: SKBR3 cell and human colon tissue lysates, MCF-7, rat epididymid tissue, human breast tissue, human kidney tissue
- Subcellular Location: Cell membrane
Target Information
B7-H4 (also known as B7x, VTCN1) is a costimulatory protein functioning as a negative regulator of T-cell mediated immunity. It likely delivers inhibitory signals to T-cells, preventing proliferation, cell cycle progression, and IL-2 production.
B7-H4 deficient mice show minimal immune defects, suggesting its role in fine-tuning immune responses. It is expressed on activated T-cells, B-cells, monocytes, and dendritic cells.
Aberrant expression has been linked to human cancers such as lung, breast, and ovarian cancer. Overexpression may help tumor cells evade immune surveillance. VTCN1 is also considered a potential biomarker for early detection of ovarian cancer and renal cell carcinoma (RCC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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