Thermo Fisher Scientific ERCC1/RAD10 (Tumor Progression Marker) Monoclonal Antibody (ERCC1/2683)
ERCC1/RAD10 단백질을 표적하는 단클론 항체로, 종양 진행 연구에 활용 가능. Western blot, ELISA, Peptide Array에 사용 가능. 인간 유래 단백질에 반응하며, IgG1 아이소타입의 마우스 항체. 단백질 A/G로 정제된 액상 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | |
| ELISA | Assay-dependent | |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ERCC1/2683 |
| Immunogen | Recombinant fragment (around aa 191–281) of human ERCC1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. It works in conjunction with SLX4 to repair interstrand cross-links (ICL) and participates in the processing of anaphase bridge-generating DNA structures. These structures arise from incompletely processed DNA lesions during S or G2 phase and can lead to cytokinesis failure. ERCC1 is also required for homology-directed repair (HDR) of DNA double-strand breaks in cooperation with SLX4. (Source: UniProt)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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