Thermo Fisher Scientific SETD7 Monoclonal Antibody (OTI5B11), TrueMAB
Human SETD7 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot 및 Flow cytometry에 적합합니다. Affinity chromatography로 정제되었으며, PBS/BSA/glycerol buffer에 보관됩니다. 히스톤 H3 Lys-4 단메틸화 연구용으로 사용됩니다.
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- TA503354
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- pk
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Applications
- Western Blot (WB): 1:500
- Flow Cytometry (Flow): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B11 |
| Immunogen | Full length human recombinant protein of human SETD7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3.
H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation.
Plays a central role in transcriptional activation of genes such as collagenase or insulin.
Recruited by IPF1/PDX-1 to the insulin promoter, leading to activated transcription.
Has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7.
Monomethylates Lys-189 of TAF10, increasing affinity for RNA polymerase II.
Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and enhancing transcriptional activation.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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