Thermo Fisher Scientific Pellino 2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, HepG2, HCT116
• Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (80%), Xenopus laevis (80%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 Lys-63-linked polyubiquitination and possibly Lys-48-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. [UniProt]

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-30701_Pellino_2_Q9HAT8-1_Rabbit.svg, PA5-30701_Pellino_2_Q9HAT8-1_Rabbit_PDP.jpeg)