Thermo Fisher Scientific Caspase 14 Polyclonal Antibody
Caspase 14 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 면역세포화학(ICC/IF)에 사용 가능. 고순도(>95%) 정제 항체이며, 액상 형태로 제공. 세포 사멸 및 각질세포 분화 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:10–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human Caspase 14 (1–242 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720767 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% as determined by SDS-PAGE.
Target Information
Caspase 14 encodes a member of the cysteine-aspartic acid protease (caspase) family, which plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits that dimerize to form the active enzyme.
This caspase is processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis-inducing ligand in vivo. Its expression and processing are associated with keratinocyte terminal differentiation, essential for skin barrier formation.
Diseases associated with CASP14 include:
- Ichthyosis, Congenital, Autosomal Recessive 12
- Autosomal Recessive Congenital Ichthyosis
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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