Thermo Fisher Scientific Phospho-PKC theta (Ser676) Polyclonal Antibody
PKC theta의 Ser676 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 고순도 정제, 1 mg/mL 농도, PBS/glycerol buffer 저장. 연구용으로 세포 신호전달 및 인산화 연구에 적합.
- 카탈로그번호
- PA599381
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRKCQ (Accession Q04759), corresponding to amino acid residues around phosphorylated Ser676 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818314 |
Product Specific Information
This antibody detects endogenous levels of PKC theta only when phosphorylated at Serine 676.
Target Information
Protein Kinase C (PKC) isoforms are serine/threonine kinases involved in signal transduction pathways that regulate various physiological processes such as differentiation, proliferation, gene expression, brain function, membrane transport, and cytoskeletal organization. PKC plays a key role in cell cycle transitions (G1 and G2 checkpoints), with effects depending on activation timing and isozyme type.
At least 12 PKC isoforms have been identified in humans (α, βI, βII, γ, δ, ε, ζ, η, θ, ι, λ, μ), differing in structure, localization, tissue distribution, and response to signals. PKC βII is expressed in cardiac muscle, intestinal epithelium, kidney, and pancreas, and is involved in cell cycle progression and cancer proliferation.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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