Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI3F8), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin.

Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin.

Factor XIII deficiency is classified into two categories:

• Type I deficiency: Lack of both the A and B subunits
• Type II deficiency: Lack of the A subunit alone

These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.