Thermo Fisher Scientific Phospho-PAK1 (Ser199, Ser204, Ser192, Ser197) Polyclonal Antibody
PAK1 단백질의 Ser199, Ser204, Ser192, Ser197 인산화 부위를 인식하는 폴리클로날 항체. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Rabbit IgG 기반, Protein A 정제, 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human PAK1 around the phosphorylation site of Ser199/204 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Three isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65, and gammaPAK p62, exhibit high sequence homology with the S. cerevisiae kinase Ste20, which is involved in pheromone signaling. The alpha, beta, and gamma PAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity and leading to autophosphorylation.
There are eight sites of autophosphorylation on gammaPAK, including Ser19, Ser141, and Thr402, and phosphorylation of Ser141 and Thr402 correlates with gammaPAK activation. Once phosphorylated, and with reduced affinity for Rac/Cdc42, PAK isoforms dissociate from the complex to act on downstream substrates.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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