Thermo Fisher Scientific CYR61 Polyclonal Antibody
Thermo Fisher Scientific의 CYR61 Polyclonal Antibody는 인간 및 랫드 시료에 반응하는 Rabbit IgG 항체입니다. Western blot에 적합하며, E.coli 유래 CCN1 단백질을 면역원으로 사용했습니다. 동결건조 형태로 제공되며, 재구성 후 500 µg/mL 농도로 사용 가능합니다. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human CCN1 recombinant protein (Position: K54–D381). Human CCN1 shares 91.8% and 92.1% amino acid sequence identity with mouse and rat CCN1, respectively. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2884870 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
CYR61 is a secreted heparin-binding protein encoded by a growth factor-inducible immediate-early gene. It associates with the extracellular matrix and connective tissue and belongs to the CCN protein family, which includes connective tissue growth factor (CTGF) and the mouse homolog Fisp12.
As an angiogenic inducer, CYR61 binds to the integrin αvβ3 receptor, stimulating cell adhesion, migration, and DNA synthesis in human vascular endothelial cells. Its expression increases during vessel growth, wound healing, and chondrocyte differentiation. CYR61 is also found in various tumors, promoting tumor growth and serving as a marker of tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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