Thermo Fisher Scientific NUDT5 Polyclonal Antibody
NUDT5 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, ELISA, IP에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 용액 형태로 제공. 인간 단백질에 반응하며 연구용으로 적합.
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- PA5112142
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:5,000–1:10,000 |
| Immunoprecipitation (IP) | 0.5–2 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ADP-sugar Pyrophosphatase/NUDT5 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866878 |
Product Specific Information
This product can be used in direct ELISA.
Target Information
NUDT5 functions as an enzyme that can act as an ADP-sugar pyrophosphatase in the absence of diphosphate or catalyze the synthesis of ATP in the presence of diphosphate. It hydrolyzes various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP, and 8-oxo-dGDP. Additionally, it can hydrolyze other nucleotide sugars with low activity. In the presence of diphosphate, it mediates ATP synthesis in the nucleus by converting ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis occurs when dephosphorylated at Thr-45 and is essential for energy-consuming chromatin remodeling events. NUDT5 binds U8 snoRNA but does not play a role in U8 snoRNA decapping activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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