Thermo Fisher Scientific Phospho-alpha B Crystallin (Ser19) Polyclonal Antibody
Phospho-alpha B Crystallin (Ser19) 폴리클로날 항체로 인간, 생쥐, 랫트 반응성. WB, IHC, ICC, ELISA 등 다양한 응용 가능. Protein A 정제, 액상 형태, -20°C 보관. 스트레스 반응 관련 단백질 연구용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser19 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to maintain the proper refractive index. The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.
Alpha-crystallin is the largest and composed of two primary gene products, alpha-A and alpha-B. Beta-crystallins and gamma-crystallins represent additional classes with multiple isoforms identified in bovine and rat lenses.
Alpha-crystallin comprises about 40% of total lens protein and functions as a molecular chaperone, preventing aggregate formation that may lead to cataracts. Phosphorylated states of alpha-crystallin occur in response to cellular stress, serving structural and maintenance roles.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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