Thermo Fisher Scientific PECAM1 Monoclonal Antibody (OTI4D1), TrueMAB
인간 PECAM1(CD31)을 인식하는 마우스 단클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 동결건조 형태로 제공되며, PBS 버퍼(8% trehalose) 내 보존제 무첨가. 재구성 및 결합 실험에 용이하며 혈관계 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D1 |
| Immunogen | Full length human recombinant protein of human PECAM1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor regulating T and B cell signaling via dual ITIM motifs. Upon phosphorylation, it provides docking sites for protein-tyrosine phosphatases. CD31 is expressed throughout the vascular compartment, primarily at cell junctions, and mediates homophilic binding through its N-terminal Ig-like domain.
It plays key roles in:
- Integrin-mediated cell adhesion
- Transendothelial migration
- Angiogenesis
- Apoptosis
- Negative regulation of immunoreceptor signaling
- Autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis
CD31 is a crucial regulatory molecule in the vascular system.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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