Thermo Fisher Scientific PLSCR1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PLSCR1 for ICC/IF applications. Recombinant human PLSCR1 immunogen, antigen affinity purified, unconjugated form. Suitable for research use in cytokine signaling and membrane phospholipid studies.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PLSCR1. Recombinant protein control fragment (Product #RP-107665). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662057 |
Product Specific Information
- Immunogen sequence: MDKQNSQMNAS HPETNLPVGY PPQYPP
- Highest antigen sequence identity to orthologs: mouse 52%, rat 44%
Target Information
Phospholipid scramblase 1 (PLSCR1) is a calcium-dependent plasma membrane protein that facilitates transbilayer movement of phosphatidylserine and other phospholipids upon cytosolic calcium influx. This process remodels the plasma membrane and exposes phosphatidylserine on the surface of injured or apoptotic cells, leading to cell death.
PLSCR1 expression is induced by interferons and cytokines, suggesting roles in cytokine signaling pathways. EGF stimulation causes tyrosine phosphorylation of PLSCR1 on residues 69 and 74, enabling interaction with Shc and linking Src kinase activation to EGF receptor signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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