Thermo Fisher Scientific CAND1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human CAND1. Recombinant protein control fragment (Product #RP-107671). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CAND1,uniProtId:Q86VP6-1,ncbiNodeId:9606,antigenRange:832-899,antigenLength:1230,antigenImageFileName:PA5-67031_CAND1_Q86VP6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-67031_CAND1_Q86VP6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2663901

Product Specific Information

Immunogen sequence: DSIRLLALLSL GEVGHHIDLS GQLELKSVIL EAFSSPSEEV KSAASYALGS ISVGNLPEYL PFVLQEI

Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.

Target Information

CAND1 enhances transcription from various types of promoters. It is a regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site. CAND1 disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.