Thermo Fisher Scientific ACVR2A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:5,000–1:20,000

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, HepG2
• Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (94%), Pig (99%), Chicken (96%), Sheep (98%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases.
ACVR2A is involved in the activin and myostatin signaling pathway.
Aliases: ACVR2, ACTRII

These receptors are transmembrane proteins composed of:

• Ligand-binding extracellular domain with cysteine-rich region
• Transmembrane domain
• Cytoplasmic domain with serine/threonine specificity

Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors.
Upon ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors.
Type II receptors are considered constitutively active kinases.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.