Thermo Fisher Scientific ACVR2A Polyclonal Antibody
ACVR2A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. Human 반응성 확인 및 다양한 종에서 예측 반응성을 보입니다. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000–1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 267–513 of Activin A Receptor type IIA (Uniprot ID: P27037) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.86 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11154389 |
Product Specific Information
- Recommended positive controls: HeLa, HepG2
- Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (94%), Pig (99%), Chicken (96%), Sheep (98%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases.
ACVR2A is involved in the activin and myostatin signaling pathway.
Aliases: ACVR2, ACTRII
These receptors are transmembrane proteins composed of:
- Ligand-binding extracellular domain with cysteine-rich region
- Transmembrane domain
- Cytoplasmic domain with serine/threonine specificity
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors.
Upon ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors.
Type II receptors are considered constitutively active kinases.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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