Thermo Fisher Scientific NUMBL Polyclonal Antibody
NUMBL 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC(P), ICC/IF 실험에 적합하며, 신경발생 과정 연구에 유용합니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NUMBL (Accession Q9Y6R0), corresponding to amino acid residues L533–A583. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851987 |
Product Specific Information
Antibody detects endogenous levels of total NUMBL.
Target Information
NUMBL plays a role in the process of neurogenesis. It is required throughout embryonic neurogenesis to maintain neural progenitor cells (radial glial cells, RGCs) by allowing their daughter cells to choose progenitor over neuronal cell fate. It is not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. NUMBL is also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. It acts as a negative regulator of the NF-kappa-B signaling pathway by preventing MAP3K7IP2 interaction with polyubiquitin chains of TRAF6 and RIPK1 and by promoting Lys-48-linked polyubiquitination and degradation of TRAF6 in cortical neurons. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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