Thermo Fisher Scientific V-ATPase D Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
VNKAQVKIRA KKDNVAGVTL PVFEHYHEGT DSYELTGLAR GGEQLAKLKR NYAKAVELLV ELASLQTSFV TLDEAIKIT

Highest antigen sequence identity to the following orthologs:

• Mouse: 100%
• Rat: 100%

Target Information

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase-dependent organelle acidification is necessary for intracellular processes such as:

• Protein sorting
• Zymogen activation
• Receptor-mediated endocytosis
• Synaptic vesicle proton gradient generation

V-ATPase is composed of:

• V1 domain (cytosolic): three A and three B subunits, two G subunits, plus C, D, E, F, and H subunits (contains ATP catalytic site)
• V0 domain (transmembrane): five different subunits (a, c, c', c'', and d)

Additional isoforms of many subunit proteins are encoded by multiple genes or alternatively spliced transcript variants.
This gene encodes the V1 domain D subunit protein.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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