Thermo Fisher Scientific Claudin 6 Monoclonal Antibody (342927)
인간 Claudin-6 단백질을 인식하는 단클론 항체로, IHC, ICC/IF, Flow Cytometry에 사용 가능. 마우스 IgG2b 형식이며 비결합형, 동결건조 형태. 세포 간 밀착연구 및 Claudin-6 관련 질환 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 8–25 µg/mL | View publication |
| Flow Cytometry (Flow) | 0.25 µg per million cells | View publication |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Published Species | Amphibian |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 342927 |
| Immunogen | NS0 mouse myeloma cell line transfected with human Claudin-6 (Met1–Val220) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608443 |
Product Specific Information
This antibody stains human Claudin-6 transfected cells but not irrelevant transfectants.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions consist of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet.
This gene encodes a component of tight junction strands and is a member of the claudin family. The protein is an integral membrane protein and serves as one of the entry cofactors for hepatitis C virus. Gene methylation may be involved in esophageal tumorigenesis. The gene is adjacent to another family member, CLDN9, on chromosome 16.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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