Thermo Fisher Scientific SAPAP3 Polyclonal Antibody
Human SAPAP3 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:20–1:50 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. 신경세포의 PSD-95 연관 단백질 연구에 적합.
- 카탈로그번호
- PA555312
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC(P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SAPAP3. Recombinant protein control fragment (Product #RP-94082). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646942 |
Product Specific Information
Immunogen sequence:
DSDSGFLAGG RPPGEPGGPF CLEGPDGSYR DLSFKGRSGG SEGRCLACTG MSMSLDGQSV KRSAWHTMMV SQGRDGYPGA GPGKGLLGPE TKAKARTYHY LQVPQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 97%
Target Information
SAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family that specifically interacts with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells.
SAPAP3 acts as an adaptor protein interacting with synaptic scaffolding proteins, cytoskeletal and signaling components such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2).
Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are mainly detected in cell bodies.
Studies suggest SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 show OCD-like behaviors that can be rescued by selective expression of SAPAP3 in the striatum.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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