Thermo Fisher Scientific Arginase 1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing Arginase 1 in human, mouse, and rat. Suitable for IHC, ICC/IF, Flow Cytometry, and ELISA. Supplied as liquid, 1 mg/mL, Protein A purified. Stored at -20°C for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Arginase 1 (amino acids 151–220) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of by-products from protein degradation. By degrading arginine, Arginase 1 limits nitric oxide synthase activity and reduces nitric oxide production.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, expression occurs in blood neutrophils but not CCR3+ granulocytes. In mice, Arginase 1 expression is a hallmark of alternatively activated macrophages (M2a). It may also be expressed in myeloid cells infiltrating tumors and is typically found in hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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